Alternatively, the inflammatory mediators may stimulate the antidromic launch on the transmitters with the collateral branches of your afferent nerves, which is often generally known as neurogenic inflammation. Neurogenic inflammation occurs when inflammatory mediators, like SP, CGRP and neurokinin (NK), are produced regionally through the afferent
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The activation of CB1 and CB2 inhibits the development of intracellular cAMP, that's why bringing about a huge reduction of the excitatory effect within the neurons [88,89]. In addition, the activation of CB2 can even further prevent the mast cell degranulation and the discharge of pro-inflammatory mediators, generating the reduction in pain sensat